Original contributionEffect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells
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2023, Biomedicine and PharmacotherapyA simple injectable peptide-based hydrogel of tanshinone ⅡA for antioxidant and anticoagulation
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :The imbalance between ROS production and antioxidant defence lead to oxidative stress, which lead to oxidation and damage of macromolecules, membranes, proteins and DNA [33]. As shown previously, Tan ⅡA was able to scavenge free radicals and prevented DNA damage caused by oxidative stress [34]. In this experiment, we aimed at evaluating the anti-oxidative activity of Nap-FFG hydrogel, Tan ⅡA and Tan@Nap-FFG hydrogel using cell viability as index.
Total synthesis of tanshinone IIA
2020, Tetrahedron LettersPharmacological properties of tanshinones, the natural products from Salvia miltiorrhiza
2020, Advances in PharmacologyPreventive and therapeutic role of Tanshinone ⅡA in hepatology
2019, Biomedicine and PharmacotherapyCitation Excerpt :Numerous experimental studies have also indicated that TIIA has a variety of biological activities, including but not limited to anti-inflammatory [13], antitumor [14], antioxidative [15], and antiplatelet aggregation effects [16]. In recent years, its positive effects in liver diseases, including anti-liver injury [17–30,32,33], anti-hepatic steatosis [38–41], anti-hepatic fibrosis [45,47–50] and anti-HCC [53–61,63–68] effects, have been widely studied. However, the underlying mechanisms of TIIA activity in liver diseases remain to be determined.