Risk factors for cerebral arteriosclerosis in Parkinson's disease

doi:10.1016/1353-8020(95)00025-9

Parkinsonism & Related Disorders

Volume 2, Issue 2, April 1996, Pages 75-79

https://doi.org/10.1016/1353-8020(95)00025-9 Get rights and content

Abstract

A previous study showed a lower incidence of ischemic stroke in patients with Parkinson's disease (PD) than in controls. It has been speculated that this may be related to less severe atherosclerosis in PD. In this study we examined the magnetic resonance imaging (MRI) and blood chemistry in 106 parkinsonian patients and compared the data with those from control cases. Abnormal MRI findings (état criblé, lacunar infarctions or periventricular hyperintensity) were found in 55.7% of cases. No case of cortical artery infarction was found. In comparison with a control population, the PD group showed a lower frequency of hypercholesterolemia, a higher frequency of low HDL cholesterol and a lower frequency of obesity. These results suggest that patients with PD have a reduction in risk factors for cortical artery infarction.

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Cited by (3)

Subclinical vascular disease and the risk of parkinsonism: The Rotterdam Study
2017, Parkinsonism and Related Disorders
Citation Excerpt :
However, there is a little prospective data on the role of subclinical vascular disease in the etiology of parkinsonism in the general population. Moreover, previous observations were focused on whether vascular pathology contribute to the disease severity in already diagnosed PD patients [16,17] or whether vascular disease co-occurred with Parkinson disease [18,19]. The main novelty of the current study is that we studied markers of several subclinical vascular pathology as risk factors of incident parkinsonism.
Parkinsonism is a common neurodegenerative syndrome in middle-aged and elderly persons. The etiology is multifactorial with a possible vascular contribution, but this has not been comprehensively studied.
To determine whether selected markers of subclinical vascular pathology are associated with the risk of all-cause parkinsonism in the general population.
We assessed a range of markers of subclinical vascular pathology (ankle-brachial index, carotid plaques and intima media thickness, retinal arteriolar and venular calibers) in 6199 persons from the population-based Rotterdam Study, who were free of parkinsonism and dementia at baseline. We followed these persons up till onset of parkinsonism, dementia, and death for 89,387 person-years until January 1, 2013. Hazard ratios (HRs) for all-cause parkinsonism and separately for Parkinson disease (PD) versus non-PD were estimated from competing risk regression models adjusting for potential confounders.
During follow-up, we identified 211 cases of parkinsonism (110 had PD). None of the five markers of subclinical pathology was associated with all-cause parkinsonism. Only low ankle-brachial index was associated with a higher risk of non-PD parkinsonism (HR = 0.79, 95%CI: 0.68–0.92), but not with the risk of PD.
We did not find a consistent pattern of associations between systemic vascular pathology markers with parkinsonism, suggesting that the potential involvement of vascular pathology is not prominent or needs further evaluation in studies with an even larger sample size.
The role of lipids in Parkinson’s disease
2019, Cells
Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G
2018, Journal of Neuroinflammation

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ArticleRisk factors for cerebral arteriosclerosis in Parkinson's disease

Abstract

Atherosclerosis

Atherosclerosis

J. Neurol. Sci.

Arteriosclerotic parkinsonism

Brain

Parkinsonism due to a basal ganglia lacunar state: clinicopathologic correlation

Neurology

Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes

Neurology

Silent lacunes in the elderly Parkinson's disease correlated with ambulatory blood pressure

Jpn. J. Geriat.

White matter hyperintensities in Parkinson's disease

Arch. Neurology

Stroke and its modification in Parkinson's disease

Stroke

Parkinsonism: onset, progression and mortality

Neurology

Criteria for diagnosing Parkinson's disease

Ann. Neurology

Article
Risk factors for cerebral arteriosclerosis in Parkinson's disease