Implications of architecture for the pathogenesis and prevention of vertebral fracture
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Cited by (191)
Characterising variability and regional correlations of microstructure and mechanical competence of human tibial trabecular bone: An in-vivo HR-pQCT study
2019, BoneCitation Excerpt :The authors further suggested that this underestimation might be due to the global derived technique employed in the HR-pQCT patient evaluation protocol, which could be improved by an advanced image-processing method [45]. The differences in proportion of plate-like and rod-like structures could affect mechanical competence of trabecular bone [43,46,47] and may be associated with postmenopausal osteoporosis [44,48]. Comparative studies of plate-like and rod-like structures were previously conducted between different parts of bones, between healthy and diseased bones [49] and between different ethnicities/races [50,51].
Soy protein improves tibial whole-bone and tissue-level biomechanical properties in ovariectomized and ovary-intact, low-fit female rats
2018, Bone ReportsCitation Excerpt :OVX also resulted in more rod-like trabeculae (i.e., increased SMI). Others have reported similar deterioration of trabecular microarchitecture in the tibia, femur, or lumbar vertebrae following OVX (Goulet et al., 2011; Parfitt, 1992; Bourrin et al., 2002; Maimoun et al., 2012; Hu et al., 2015; Dai et al., 2008; Ahn et al., 2014; Li et al., 2011; Bagi et al., 1996; Cai et al., 2005; Blum et al., 2003; Jee and Yao, 2001), and BV/TV of the proximal tibia was significantly reduced in LCR rats 4 weeks after OVX relative to LCR rats that underwent sham surgery (Goulet et al., 2011). Tb.N reflects osteoclast activity (Parfitt, 1992; Bourrin et al., 2002); therefore, we conclude that the loss of trabeculae observed in the present study was likely mediated by increased osteoclast activity, which is consistent with the significant increase in CTx in OVX animals.
A novel use of 3D printing model demonstrates the effects of deteriorated trabecular bone structure on bone stiffness and strength
2018, Journal of the Mechanical Behavior of Biomedical MaterialsObesity and type 2 diabetes, not a diet high in fat, sucrose, and cholesterol, negatively impacts bone outcomes in the hyperphagic Otsuka Long Evans Tokushima Fatty rat
2017, BoneCitation Excerpt :This localized reduction in bone volume is likely because trabeculae exposed to the lowest stresses are the first locations of bone resorption [83]. Perforation of trabeculae and ultimately complete removal can occur as a result of trabecular thinning, increased frequency of remodeling activation, and/or increased resorption depth [84]. Tb.Th and variability in Tb.Th were not affected by T2D, suggesting that increased remodeling frequency or erosion pit depth were responsible for the loss of trabeculae in OLETF rats.