Original articleHigh bone turnover is associated with low bone mass in both pre- and postmenopausal women
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2021, BoneCitation Excerpt :Recently, two histomorphometry studies with vertebra and iliac crest bone biopsies suggested higher bone turnover in AIS patients requiring surgery, which was associated with larger osteoid area, less osteocyte and more osteoblast number [9,10]. High bone turnover is speculated to contribute to low BMD [11] and significantly modulate bone microarchitecture [12]. However, it is yet unclear whether abnormal bone turnover could be associated with curve progression in AIS.
Associations between the serum levels of selected bone turnover markers and biological traits in nursing home women aged 80+ without inflammation. A pilot study
2020, Experimental GerontologyCitation Excerpt :A number of national and international organizations dedicated to osteoporosis (including the International Osteoporosis Foundation (IOF), the US National Osteoporosis Foundation (NOF), and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)) recommend using BTMs in preventing, detecting and treating osteoporosis. Generally, the correlation between the levels of BTMs and BMD in postmenopausal women is weak (Ravn et al., 1996; Garnero et al., 1996; Chung et al., 2000), as opposed to the association between BTMs and the risk of fracture independent of BMD, which is significant (Garnero, 2008; Morris et al., 2017; Ross et al., 2000). The pattern may be due to a biological variability and according to many researchers the appropriate age- and gender-specific groups
Bisphosphonate-osteoclasts: Changes in osteoclast morphology and function induced by antiresorptive nitrogen-containing bisphosphonate treatment in osteoporosis patients
2014, BoneCitation Excerpt :Our study lends support to this theory due to the fact that while osteoclast number was similar compared to baseline, bone volume as evidenced in micro-CT results (+ 1,7%/year BV/TV [29]) increased during the course of 3 years. A high bone turnover was reported to be associated with a reduced bone mass in postmenopausal women [61]. Antiresorptive treatments, bisphosphonates in particular, have been shown to decrease the overall bone turnover, incl. osteoblastic formation, secondary to the reduction in bone resorption [62,63].
Reference intervals of biochemical bone turnover markers for Saudi Arabian women: A cross-sectional study
2010, BoneCitation Excerpt :The increases in markers of bone resorption tend to be greater than that of bone formation: u-CTX (by 91.2%); u-DPD (by 80.6%); u-NTX (by 72.3%); and s-TRACP-5b (by 38.5%), respectively. Several studies showed similar changes: urinary deoxypyridinolines and urinary telopeptides increased by 2-fold [42–48]. However it is uncertain whether the onset of the changes in the biochemical BTMs takes place early in the menopausal transition or before the cessation of menstruation.
Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient
2010, Journal of Steroid Biochemistry and Molecular BiologyThe primary care osteoporosis risk of fracture screening (POROS) study: Design and baseline characteristics
2010, Contemporary Clinical TrialsCitation Excerpt :The World Health Organization's fracture risk assessment (FRAX) may be a useful tool to help risk stratify women with osteopenia [3–6]. Other strategies to assess the risk of bone loss and fractures in this early postmenopausal group may include measurement of bone turnover markers, such as urine N-telopeptide (NTx) [7–10]. A baseline BMD is a static assessment of the measured skeletal sites.