Bone scanning: Radionuclidic reaction mechanisms+
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Cited by (114)
Dosimetry of Bone Seeking Beta Emitters for Bone Pain Palliation Metastases
2022, Seminars in Nuclear MedicineCitation Excerpt :Studies demonstrated that diphosphonates strongly bind to calcium phosphates, including hydroxyapatite. Microautoradiographic studies indicated that radiolabeled diphosphonates do not bind to osteoid but within calcified trabecular bone, below the osteoid layer.41 The metabolism of pyrophosphate and diphosphonate showed a chemical bond to the surface of hydroxyapatite.
Osteomyelitis of the Thumb in a 21-Year-Old Chiropractic Patient: A Case Report
2018, Journal of Chiropractic MedicineCitation Excerpt :A radionuclide scan may detect a bone infection as early as 2 days after the onset.18 A positive bone scan does not specifically make the diagnosis but does measure the increase blood flow and reactive new bone formation seen in osteomyelitis.19 Bone scans have a high sensitivity and a poor specificity.
SPECT/CT in Postoperative Foot and Ankle Pain
2018, Seminars in Nuclear MedicineCitation Excerpt :However, quality and resolution of both MRI and CT images are often impaired by artifacts from metal implants or even from microscopic metal wear.6 Bone scintigraphy using Technetium-99m-labeled bisphosphonates is performed to evaluate bone pathology on a functional level with the intensity of tracer uptake depending on regional blood flow, osteoblastic activity, and on altered sympathetic nerve supply.7 With regard to the clinical situation, a correlation between bone pain and the degree of radionuclide uptake was described more than 30 years ago.8
Semi-quantitative analysis of scintigraphic findings in the hands of adults without osteoarticular disease
2017, Revista Colombiana de ReumatologiaThe bone scan
2012, Seminars in Nuclear MedicineCitation Excerpt :Osteoblasts form an osteoid matrix that is later mineralized with hydroxyapatite crystals. 99m-Tc diphosphonates chemisorb6 and bind to the hydroxyapatite crystals in proportion to local blood flow and osteoblastic activity and are therefore markers of bone turnover and bone perfusion. They rapidly localize to bone and clear quickly from background, making them favorable for imaging.
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Supported in part by USPHS Grant GM 18674.
- 1
From the Department of Radiology, Harvard Medical School and Peter Bent Brigham Hospital, Boston, Mass., and Miami Valley Laboratories, the Procter & Gamble Company, Cincinnati, Ohio.
- 2
Alun G. Jones, Ph.D.: Associate in Radiology, Harvard Medical School, Boston
- 3
Mass. Marion D. Francis, Ph.D.: Senior Scientist, Research and Development Department, Miami Valley Laboratories, the Procter & Gamble Company, Cincinnati, Ohio
- 4
Michael A. Davis, Sc.D.: Assistant Professor of Radiology, Harvard Medical School, Boston, Mass.