Brief report
Effect of vitamin E on the anticoagulant response to warfarin

https://doi.org/10.1016/S0002-9149(97)89357-5Get rights and content

Abstract

Contrary to recent recommendations,13 our findings suggest that moderate to large doses of vitamin E can be safely used in patients receiving warfarin, and that treatment with vitamin E is not contraindicated in these patients. However, because it is always wise to retest the INR or prothrombin time several days after starting a new drug, we recommend retesting the INR approximately 1 to 2 weeks after starting vitamin E therapy.

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    Citation Excerpt :

    The degree of bleeding risk associated with vitamin E remains controversial and caution is warranted in women taking warfarin. Concomitant use of vitamin E with antiplatelet agents like aspirin might increase the risk of bleeding by inhibiting platelet aggregation [36] However, a clinical trial with warfarin and vitamin E showed no increased risk of bleeding [37]. Cranberry juice, though implicated in case reports, has not been shown to affect coagulation in a controlled study [38].

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Dr. White's address is: Division of General Medicine, Room 3107, PCC, 2221 Stockton Boulevard, Sacramento, California 95817.

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