Brief ReportsIntravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation1
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Cited by (76)
Resuscitation and Preparation of the Emergency General Surgery Patient
2023, Surgical Clinics of North AmericaVitamin K for reversal of excessive Vitamin K antagonist anticoagulation: A systematic review and meta-analysis
2019, Blood AdvancesCitation Excerpt :In addition, we excluded 5 RCTs that the previous systematic review included. These RCTs were excluded because VKA was not temporarily discontinued in the treatment group26 or because they compared different doses or routes of administration for vitamin K, rather than against placebo or observation only.22,27-29 Finally, DeZee et al10 included nonrandomized studies, whereas we focused on RCTs only.
Anticoagulation Reversal
2018, Emergency Medicine Clinics of North AmericaCitation Excerpt :Vitamin K is an essential cofactor in the synthesis of factors II, VII, IX, and X, and proteins C and S. Vitamin K is available in both oral and IV forms. Subcutaneous and intramuscular administration are no longer recommended owing to unpredictable absorption and the potential for hematomas.21 Time to onset after the administration of oral vitamin K is 6 to 10 hours, with peak activity occurring within 24 to 48 hours.21–23
Blood Component and Pharmacologic Therapy for Hemostatic Disorders
2013, Consultative Hemostasis and Thrombosis: Third EditionCan asymptomatic patients with a supratherapeutic international normalized ratio be safely treated as outpatients?
2012, Annals of Emergency Medicine
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