Clinical studyAnalysis of plasma histamine levels in patients with mast cell disorders
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2022, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Thirty percent of the patients with indolent (I)SM had a normal initial plasma histamine level. Furthermore, a circadian pattern of plasma histamine levels was found in patients with SM, with highest levels around 2:00 AM and lowest values at approximately 2:00 PM.81 The circadian pattern of plasma histamine levels has also been found in other groups including normal volunteers, and diurnal variation in urinary histamine levels has been reported both in patients with asthma and in normal volunteers.82,83
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