Oncogene expression in follicular neoplasms of the thyroid

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Oncogene expression has been found to be a potential marker for aggressive biologic behavior in certain tumors. We studied 21 follicular adenomas and 20 follicular carcinomas by immunocytochemistry utilizing specific monoclonal antibodies against HER-2/neu and c-myc oncogenes. Survival data were obtained from our institution's tumor registry.

No expression of the HER-2/neu oncogene was found in the specimens studied. Cytoplasmic staining for c-myc was observed in 3 of 21 adenomas (14%) and 9 of 20 (45%) carcinomas (p<0.05). The incidence of local, regional, and distant metastases was not significantly different in c-myc(+) and c-myc(−) patients.

The c-myc oncogene is expressed more often in malignant than in benign follicular neoplasms of the thyroid, but its expression does not appear to be a good prognostic indicator.

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Presented at the Third International Conference on Head and Neck Cancer, San Francisco, California, July 26–30, 1992

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From the Section of Surgical Oncology (LJA, AW, CB, JA), Department of Surgery and the Department of Pathology (EV), Long Island Jewish Medical Center, New Hyde Park, New York, the Long Island Campus of Albert Einstein College of Medicine, Long Island, New York, and the University of Florida Health Science Center (SM), Jacksonville, Florida.

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