Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers*
References (36)
- et al.
CD27: a marker and mediator of T-cell activation?
Immunology Today
(1994) - et al.
CD40 ligand and its role in X-linked hyper-IgM syndrome
Immunology Today
(1993) - et al.
Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
Molecular Immunol
(1987) - et al.
Crosslinking of OX-40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic
B cells. Immunity
(1995) - et al.
CD28/B7 system of T cell co-stimulation
Ann Rev Immunol
(1996) - et al.
Adoptive immunotherapy of established syngeneic solid tumors: role of T-lymphoid cell populations
J Immunol
(1984) - et al.
The tumor necrosis factor ligand and receptor families
NEJM
(1996) - et al.
Identification of a human Ox40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
J Exp Med
(1994) - et al.
The OX-40 antibody selects for autoantigen specific V beta 8.2 + T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis
J Neurosci Res
(1996) - et al.
Target organ specific up regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis
J Immunol
(1994)
High gradient magnetic cell separation with MACS
Cytometry
(1990)
Single step method of RNA isolation by acid guanidinium thiocyanated-pheno-chloroform extraction
Ann Biochem
(1987)
Immunity to TCR peptides in multiple sclerosis: T cell recognition of V beta 5.2. V beta 6.1. CDR2 peptides
J Immunol
(1994)
Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood
J Immunol
(1992)
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Nature
(1992)
Identification of a human OX-40 ligand, a co-stimulator of CD4+ T cells with homology to tumor necrosis factor
J Exp Med
(1994)
Molecular characterization of immune and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
EMBO
(1994)
Characterization of the MRC OX-40 antigen of activated CD4 positive T lymphocytes—a molecule related to nerve growth factor receptor
EMBO
(1990)
Cited by (102)
The dynamic role of immune checkpoint molecules in diagnosis, prognosis, and treatment of head and neck cancers
2024, Biomedicine and PharmacotherapyImmune Evasion by Head and Neck Cancer: Foundations for Combination Therapy
2019, Trends in CancerCitation Excerpt :One promising co-stimulatory molecule is Ox40, which is expressed on the surface of T cells and promotes proliferation, IFNγ production, and memory formation [63]. Expression of Ox40 has been demonstrated on the surface of HNSCC tumor cells and in draining lymph nodes [64], but expression of its ligand (Ox40L) is reduced in the tumor and thus this pathway is rendered ineffective at generating an antitumor immune response [65,66]. Therefore, potential exists to augment the Ox40 pathway in HNSCC with receptor agonists, which are currently being tested in this setting in clinical trials (discussed below).
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma
2017, European Journal of CancerFirst-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
2022, Clinical Cancer Research
- *
Presented at the 87th Annual Meeting of the American Association for Cancer Research, Washington, DC, April 20–24, 1996.
Copyright © 1997 Published by Elsevier Inc.