Original article: general thoracicThe natural history of recurrence after bronchoplastic procedures for non-small cell lung cancer
Section snippets
Patients and methods
Between December 1993 and July 2001 109 bronchoplastic procedures were performed in our department. Histiocytoma, adenoidcystic carcinoma, neuroendocrine carcinoma grade I and III, and metastasis of extrathoracic origin were excluded from analysis.
Postoperative routine follow-up consisted of a bronchoscopy, chest roentgenography, chest computed tomography (CT) every 6 months during the first 2 postoperative years and annual restagings from the third to the fifth postoperative year. Radiologic
Results
Eighty-three patients were included in the study. Only 1 patient was lost to follow-up. There were 66 men (79.5%) and 17 women (20.5%) aged between 26 and 76 years old (mean 58.4 years old, median 61 years old, SD 10.67). Five patients received neoadjuvant chemotherapy.
Comment
The question of postoperative tumour recurrence not only depends on local surgical radicality (which of course remains the primary goal of resection). E.g. the detection of malignant cells in preoperative pleural lavage negatively influences long term survival and underlines the problem of clinical and histological understaging [7]. The negative prognostic influence of Dehydrol-dehydrogenase present in tumour tissue points at the influence of molecular mechanisms which are not evaluated in
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