Congenital Cardiac Anomalies Associated with the DiGeorge Syndrome: A Neonatal Experience
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Resource Use and Morbidities in Pediatric Cardiac Surgery Patients with Genetic Conditions
2018, Journal of PediatricsCitation Excerpt :Although our study was multicenter and had a larger number of subjects, previous single-center reports did not find increased frequency of infection after surgery.24-26 The etiology of increased nosocomial and postoperative infections in 22q11 may be attributable to impaired immunologic function and lower T-cell production.28,29 Given that reimbursement rates can be threatened when nosocomial infections occur, it is important to highlight that not all CHD repairs carry equal risk of infection.
22q11.2 Deletion syndrome is associated with increased perioperative events and more complicated postoperative course in infants undergoing infant operative correction of truncus arteriosus communis or interrupted aortic arch
2014, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :The observed differences in our study were not the result of infectious adverse events, for which no differences were found between the 22q11del-positive and -negative subjects. This is in contrast to earlier studies that identified immunodeficiency and associated infections as a source of tremendous morbidity and mortality15 and consistent with more recent studies that have not observed a difference in infectious complications.16,31 Likewise, no difference was found in the incidence of noncardiac events overall between the 22q11del-positive and -negative subjects.
Perioperative management of patients with DiGeorge syndrome undergoing cardiac surgery
2014, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :This patient had low T-cell and B-cell counts and IgG and IgM deficiencies and required intravenous immunoglobulin in addition to antibiotic therapy to treat postoperative pneumonia, urinary tract infection, and otitis media. The improvement in survival observed by Kyburz et al6 and this series compared with Marmon et al,7 which represented an earlier era, probably reflects improvement in the perioperative care of congenital cardiac surgical patients. Another difference is that Marmon et al7 series included only neonates, whereas these patients were generally older children, which can influence the rates of complications.
Combination of Aortopulmonary Window and Complete Atrioventricular Septal Defect in a Patient With Heterotaxy Syndrome
2009, Annals of Thoracic SurgeryCitation Excerpt :However, an AP window is not seen when the neural crest is removed [3]. In addition, AP window has not been reported in association with DiGeorge syndrome [4, 5]. Partitioning of the AV canal begins about the middle of the fourth week of gestation and is essentially complete by the end of the fifth week.
Deletion of chromosome 22q11.2 and outcome in patients with pulmonary atresia and ventricular septal defect
2003, Annals of Thoracic SurgeryCommon arterial trunk, DiGeorge syndrome and microdeletion 22q11
2002, Progress in Pediatric Cardiology