Robenzidene, an inhibitor of oxidative phosphorylation

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Robenzidene at 20 μM, inhibits the ADP stimulated respiration of intact rat liver mitochondria and induces respiratory control in submitochondrial fragments. At concentrations of the order of 16 nmole per mg protein, it also inhibits the Cl-CCP induced ATPase of mitochondria and ATPase of mitochondrial fragments. These properties of robenzidene resemble those of other inhibitors of oxidative phosphorylation such as oligomycin and DCCD.

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