Biochemical and Biophysical Research Communications
Volume 46, Issue 2, 31 January 1972, Pages 621-627
Robenzidene, an inhibitor of oxidative phosphorylation
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2019, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :Despite robenidine being used for the past 40 years as an anticoccidial agent its mechanism of action against protozoa is not known. Previous studies of the mechanism of action of robenidine have been inconclusive with some suggesting that ATPase is the primary target while others have identified no obvious morphological effect in E. tenella on mitochondria or the nucleus, with chiefly the Golgi body and endoplasmic reticulum being affected (Lee and Millard, 1972; Wong et al., 1972). In the same study, swelling of the perinuclear space was noted, it was suggested this could be due to the overproduction of proteins potentially indicating an increase in metabolism causing the cells to self-destruct (Lee and Millard, 1972).
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