Short communicationIncreased granule cell neurogenesis in the adult dentate gyrus following mossy fiber stimulation sufficient to induce long-term potentiation
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Acknowledgements
Supported by MH 10165 to A.D.Y., DA11983 to B.E.D., and DA04195 and NSF 94-11564 to J.L.M. We thank Crystal Rublee and Viet Do for technical assistance. These experiments were conducted in the Department of Psychology at the University of California at Berkeley. Post-experimental analysis was conducted at both the University of Texas at San Antonio and The University of Alaska.
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2021, Cell ReportsCitation Excerpt :Thus, neuronal activity and neurogenesis exhibit an anatomical relationship on such a small scale of a few hundred micrometers. Previous studies have indicated a local relationship at the level of brain structure (Bruel-Jungerman et al., 2006; Derrick et al., 2000; Dong et al., 2019; Song et al., 2012; Stone et al., 2011; Yeh et al., 2018), but not to such a high spatial resolution of a few hundred micrometers. These anatomical relationships indicate that a local neurogenic niche can be defined by these electrophysiological features and suggest that all or some of these electrophysiological features may be involved in a local regulation of structural and molecular characteristics of a microenvironment facilitating and/or inhibiting neurogenesis.
The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?
2012, NeuropharmacologyCitation Excerpt :However, in the early 2000’s, the functional relevance of adult-generated hippocampal neurons was not clear. There were many correlative studies suggesting its importance in learning and memory (e.g. Derrick et al., 2000; Dobrossy et al., 2003; Gould et al., 1999; Kempermann et al., 1997; van Praag et al., 1999a), and a few studies using constitutive knockout mice (Feng et al., 2001), but no study had inducibly and specifically decreased neurogenesis to explore its functional relevance. Inducible ablation of adult neurogenesis was first done in studies using cranial irradiation or antimitotics agents (Madsen et al., 2003; Mizumatsu et al., 2003; Monje et al., 2002; Parent et al., 1999; Peissner et al., 1999; Raber et al., 2004; Shors et al., 2002; Snyder et al., 2001; Uberti et al., 2001).
Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes
2007, NeuroscienceCitation Excerpt :These findings are of importance as they demonstrate learning-associated T cell activity in the brain of non-traumatized animals. Indeed, HFS-LTP and learning have clearly been associated with enhanced granule cell neurogenesis (Gould et al., 1999; Derrick et al., 2000; Bruel-Jungerman et al., 2006; Chun et al., 2006). In urethane-anesthetized rats, we evoked an enduring form of HFS-LTP that showed early elevated expression of known LTP-linked and NMDAR-dependent genes (zif268, neuritin and others).