Elsevier

Brain Research

Volume 857, Issues 1–2, 28 February 2000, Pages 300-307
Brain Research

Short communication
Increased granule cell neurogenesis in the adult dentate gyrus following mossy fiber stimulation sufficient to induce long-term potentiation

https://doi.org/10.1016/S0006-8993(99)02464-6Get rights and content

Abstract

Neurons are continually added at a low rate to the granule cell layer of the dentate gyrus during adulthood in rats. The functional significance of this unusual feature is not completely understood, although recent studies suggest continued granule cell neurogenesis is essential for normal learning and memory. We report here that, in the adult rat, stimulation of the granule cell mossy fibers sufficient to induce long-term potentiation (LTP) increases the number of newly formed granule cells in the dentate gyrus, indicating that granule cell neurogenesis is regulated by efferent activity and, possibly, the induction of LTP.

Section snippets

Acknowledgements

Supported by MH 10165 to A.D.Y., DA11983 to B.E.D., and DA04195 and NSF 94-11564 to J.L.M. We thank Crystal Rublee and Viet Do for technical assistance. These experiments were conducted in the Department of Psychology at the University of California at Berkeley. Post-experimental analysis was conducted at both the University of Texas at San Antonio and The University of Alaska.

References (27)

  • H. Cameron et al.

    Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus

    J. Neurosci.

    (1995)
  • B.E. Derrick et al.

    Opioid receptor activation is one factor underlying the frequency dependence of mossy fiber LTP induction

    J. Neurosci.

    (1994)
  • B.E. Derrick et al.

    Bidirectional associative synaptic plasticity at the hippocampal mossy fiber-CA3 synapse

    Nature

    (1996)
  • Cited by (69)

    • Hippocampal circuits

      2022, Neurocircuitry of Addiction
    • A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus

      2021, Cell Reports
      Citation Excerpt :

      Thus, neuronal activity and neurogenesis exhibit an anatomical relationship on such a small scale of a few hundred micrometers. Previous studies have indicated a local relationship at the level of brain structure (Bruel-Jungerman et al., 2006; Derrick et al., 2000; Dong et al., 2019; Song et al., 2012; Stone et al., 2011; Yeh et al., 2018), but not to such a high spatial resolution of a few hundred micrometers. These anatomical relationships indicate that a local neurogenic niche can be defined by these electrophysiological features and suggest that all or some of these electrophysiological features may be involved in a local regulation of structural and molecular characteristics of a microenvironment facilitating and/or inhibiting neurogenesis.

    • The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

      2012, Neuropharmacology
      Citation Excerpt :

      However, in the early 2000’s, the functional relevance of adult-generated hippocampal neurons was not clear. There were many correlative studies suggesting its importance in learning and memory (e.g. Derrick et al., 2000; Dobrossy et al., 2003; Gould et al., 1999; Kempermann et al., 1997; van Praag et al., 1999a), and a few studies using constitutive knockout mice (Feng et al., 2001), but no study had inducibly and specifically decreased neurogenesis to explore its functional relevance. Inducible ablation of adult neurogenesis was first done in studies using cranial irradiation or antimitotics agents (Madsen et al., 2003; Mizumatsu et al., 2003; Monje et al., 2002; Parent et al., 1999; Peissner et al., 1999; Raber et al., 2004; Shors et al., 2002; Snyder et al., 2001; Uberti et al., 2001).

    • Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes

      2007, Neuroscience
      Citation Excerpt :

      These findings are of importance as they demonstrate learning-associated T cell activity in the brain of non-traumatized animals. Indeed, HFS-LTP and learning have clearly been associated with enhanced granule cell neurogenesis (Gould et al., 1999; Derrick et al., 2000; Bruel-Jungerman et al., 2006; Chun et al., 2006). In urethane-anesthetized rats, we evoked an enduring form of HFS-LTP that showed early elevated expression of known LTP-linked and NMDAR-dependent genes (zif268, neuritin and others).

    View all citing articles on Scopus
    View full text