Review
The carrier state in foot and mouth disease—an immunological review

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Summary

The carrier state in foot and mouth disease (FMD) is characterized by the asymptomatic low-level excretion of foot and mouth disease virus (FMDV) from the oropharynx of ruminants for periods that are species and virus strain-dependent. Persistent infection with FMDV readily occurs following the failure of virus elimination at the acute stage of infection, a process thought to be mediated through the phagocytosis of antibody/virus immune complexes. Recent evidence supports the view that carrier cattle are important in the epidemiology of FMD in the field. The absence of histopathological change in persistently infected tissues and the reduced cytopathology of carrier virus isolates in tissue culture suggest that less lytic FMDV variants are generated or selected in the carrier animal. Altered virus replication, due to attenuation or interference, rather than antigenic variation may therefore allow evasion of the exaggerated FMDVspecific systemic and local humoral immune responses that occur in the carrier state. Although cell-mediated immune mechanisms for FMDV clearance have not been described, the eventual elimination of many persistent virus infections involves this arm of the immune system. Thus, further investigation of cellular elements of the immune response, more particularly the local interaction of mononuclear cell infiltrates with persistently infected cells, represents an area of research that has the potential to elucidate the carrier state problem.

References (87)

  • MulcahyG. et al.

    Isotype responses of infected, virus-vaccinated and peptide-vaccinated cattle to foot and mouth disease virus

    Vaccine

    (1990)
  • MulcahyG. et al.

    The mouse protection test as a predictor of the protective capacity of synthetic foot and mouth disease vaccines

    Vaccine

    (1991)
  • NeitzertE. et al.

    Expression of the aphthovirus RNA polymerase gene in E. coli and its use together with other bioengineered non-structural antigens in the detection of late persistent infection

    Virology

    (1991)
  • TrautmanR. et al.

    Detection and properties of a genomic masked viral particle consisting of foot and mouth disease virus nucleic acid in bovine enterovirus protein capsid

    Virology

    (1971)
  • VillaverdeA. et al.

    Fixation of mutations at the VP1 gene of foot and mouth disease virus. Can quasispecies define a transient molecular clock?

    Gene

    (1991)
  • AhlR. et al.

    Infectivity of foot and mouth disease carrier virus and virus population characteristics during infection

  • AhmedR. et al.

    The molecular basis of organ-specific selection of viral variants during chronic infection

    J. Virol.

    (1991)
  • AmadoriM. et al.

    Humoral and cellular parameters of experimental foot and mouth disease in heifers

    J. vet. Med.

    (1987)
  • AmadoriM. et al.

    Isolation of mononuclear cytotoxic cells from cattle vaccinated against foot and mouth disease

    Arch. Virol.

    (1992)
  • AndersonE.C. et al.

    The effect of repeated vaccination in an enzootic foot and mouth disease area on the incidence of virus carrier cattle

    J. Hyg.

    (1974)
  • AndersonE.C. et al.

    The role of sheep and goats in the epizootiology of foot and mouth disease in Kenya

    J. Hyg.

    (1976)
  • Auge De MelloP. et al.

    Further information on the survival of modified foot and mouth disease virus in cattle

    Bull. Off. Int. Epizoot.

    (1970)
  • BengisR.G. et al.

    Foot and mouth disease and the African buffalo (Syncerus caffer)

    Onderstepoort J. Vet. Res.

    (1986)
  • BorcaM.V. et al.

    The immune response to foot and mouth disease virus in a murine experimental model: effective T-independent 1° and 2° reaction

    Immunology

    (1986)
  • BorrowP. et al.

    Infection of lymphocytes by a virus that aborts cytotoxic T lymphocyte activity and establishes persistent infection

    J. exp. Med.

    (1991)
  • BrooksbyJ.B.

    Variants and immunity: definitions for serological investigation

  • BrownF. et al.

    Further studies of the early antibody in the sera of cattle and guinea pigs infected with foot and mouth disease virus

    J. Immunol.

    (1964)
  • BurrowsR.

    Studies on the carrier state of cattle exposed to foot and mouth disease virus

    J. Hyg., Camb.

    (1966)
  • BurrowsR.

    The persistence of FMDV in sheep

    J. Hyg., Camb.

    (1968)
  • CaoX. et al.

    Comparison of the 5′ and 3′ untranslated genomic regions of virulent and attenuated foot and mouth disease viruses (strains O1 Campos and C3 Resende)

    J. Gen. Virol.

    (1991)
  • CollenT. et al.

    Induction of antibody to foot and mouth disease virus in presensitized mouse spleen cell cultures

    J. Virol.

    (1984)
  • CollenT. et al.

    T cell-dependent induction of antibody against foot and mouth disease virus in a mouse model

    J. Gen. Virol.

    (1989)
  • CollenT. et al.

    Heterotypic recognition of foot and mouth disease virus by cattle lymphocytes

    J. Gen. Virol.

    (1990)
  • CollenT. et al.

    A T cell epitope in VP1 of foot and mouth disease virus in immunodominant for vaccinated cattle

    J. Immunol.

    (1991)
  • Costa GiomiM.P. et al.

    Heterogeneity of the poly(C) tract in aphthoviruses: biochemical and biological studies of viruses carrying poly(C) tracts of different lengths

    J. Virol.

    (1984)
  • CottralG.E.

    Persistence of foot and mouth disease virus in animals, their products and the environment

    Bull. Off. int. Epiz.

    (1969)
  • DiezJ. et al.

    Foot and mouth disease virus strains isolated from persistently infected cell cultures are attenuated for mice and cattle

    Virus Res.

    (1990)
  • DiezJ. et al.

    Unique amino acid substitutions in the capsid proteins of foot and mouth disease viruses from persistent infection in cell culture

    J. Virol.

    (1990)
  • DigirolamoW. et al.

    Role of Langerhans cells in the infection of the guinea pig epidermis with foot-and-mouth disease virus

    Arch. Virol.

    (1985)
  • DomingoE. et al.

    Genetic variability and antigenic diversity of foot and mouth disease virus

  • FellowesO.N. et al.

    Foot and mouth disease virus: biological characteristics of virus from bovine carriers

    Arch. ges Virusforsch.

    (1970)
  • FrancisM.J. et al.

    The antibody response in pig nasal fluid and serum following foot and mouth disease infection or vaccination

    J. Hyg., Camb.

    (1983)
  • GarlandA.J.M.

    The inhibitory activity of secretions in cattle against foot and mouth disease virus

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