Subacute inhalation toxicity of mineral oils, C15–C20 alkylbenzenes, and polybutene in male rats

doi:10.1016/S0013-9351(05)80129-X

Environmental Research

Volume 53, Issue 1, October 1990, Pages 48-61

https://doi.org/10.1016/S0013-9351(05)80129-X Get rights and content

Male Wistar rats were exposed to mist and vapor of two mineral oils, two C₁₅–C₂₀ alkylbenzenes, and one polybutene at aerosol concentrations of 70 mg·m⁻³ and 700 mg·m⁻³ for 2 weeks. Of oil mist particles, 82–97 wt% were respirable (<4.7 μm). High-level exposure to polybutene was lethal to three of four animals, due to pulmonary edema. Elevated numbers of pulmonary macrophages and increased macrophage vacuolization were observed after exposure to the polybutene, both mineral oils, and one alkylbenzene. The same alkylbenzene produced body weight loss. Deposition analysis was performed for one mineral oil. No oil was detected in brain tissue, while retroperitoneal fat tissue contained 541 (401–702) μg oil/g tissue, half of this still present after an exposure-free period of 2 weeks. It is concluded that inhalation of the polybutene and one of the mineral cable oils tested here produces toxic effects in lung.

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¹: Present address: Medical Department, Alcatel-STK A/S, P.O. Box 60, Økern, N-0508 Oslo 5, Norway.

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Subacute inhalation toxicity of mineral oils, C15–C20 alkylbenzenes, and polybutene in male rats

Toxicol. Appl. Pharmacol.

Pathology

Environ. Res.

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J. Toxicol. Environ. Health

Statistics. A Biomedical Introduction

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Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Polynuclear Aromatic Hydrocarbons. Part 2. Carbon Blacks, Mineral Oils and Some Nitroarenes

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Subacute inhalation toxicity of mineral oils, C₁₅–C₂₀ alkylbenzenes, and polybutene in male rats