Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles

doi:10.1016/S0015-0282(16)54541-5

Fertility and Sterility

Volume 56, Issue 3, September 1991, Pages 465-468

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Objective

Assessment of the effects of clomiphene citrate (CC) on cervical mucus score and in vitro sperm mucus interaction.

Design

Prospective study of cervical mucus score and in vitro sperm mucus interaction in a spontaneous cycle followed by a CC cycle to compare paired data.

Setting

Tertiary institutional infertility clinic.

Patients, Participants

Twenty-two couples with primary unexplained infertility were studied in both cycles.

Interventions

Clomiphene citrate (150 mg) on days 5 to 9 in CC cycles.

Main Outcome Measures

Cervical mucus score and sperm-mucus penetration test score.

Results

Mean cervical mucus score in spontaneous cycles was 9.3 (95% confidence interval [CI] 8.4 to 10.2) and in CC cycles 5.6 (95% CI 4.6 to 6.6), P < 0.0001. Sperm-mucus penetration test score in spontaneous cycles was 11.4 (95% CI 7.6 to 15.2) and in CC cycles 3.9 (95% CI 1.17 to 6.63), P < 0.01.

Conclusions

Clomiphene citrate has an adverse effect on both cervical mucus score and sperm-mucus penetration.

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^*: Supported by grant no. KMRS SOC898 from the Scottish Home and Health Department, Edinburgh, Scotland.

^†: Reprint requests and present address: John M. Randall, M.D., Department of Obstetrics and Gynaecology, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, United Kingdom BD9 6RJ.