A Rapid Screening Procedure for Quaternary Ammonium Compounds in Fluids and Tissues with Special Reference to Suxamethonium (Succinylcholine)

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The extraction of suxamethonium from urine samples in the form of its ion-pair complex with bromothymol blue is described. Detection of the drug was accomplished colorimetrically and enzymically using two thin-layer chromatography systems, and one gas chromatographic method.

A brief study was made of the stability of suxamethonium at various pH values which affect its storage in urine for different periods of time.

The extraction technique and colorimetric method of detection were applied to other quaternary ammonium compounds, some of which had been recovered from blood and urine after addition to these fluids. This work also included a short study of the effect of certain tertiary amine drugs if present in the urine with the quaternary compounds.

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