Comparison of the Clinicopathologic Features of Primary Sclerosing Chol-angitis and Primary Biliary Cirrhosis+,++,+++
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2016, Journal of HepatologyCitation Excerpt :Czaja et al. found that 24% of patients with “classical AIH” had biliary changes on biopsy, including destructive cholangitis, ductopenia, and non-destructive cholangitis [11] but concluded on further investigation that these patients lacked the features of PBC [12]. Conversely, the “florid duct lesion”, classically found in PBC, is not always present and granulomatous cholangitis was seen in only 32% of PBC patients in one study [13]. In PSC, the classical histology findings are portal tract inflammation with lymphocytic infiltration in the bile ducts and ductular proliferation [14].
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This research was supported by National Institutes of Health grants AM19448 and RR585, by a grant from Merck, Sharp, and Dohme, and by the Mayo Foundation. Data analysis was performed using the CLINFO Data Analysis System.
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Part of this work was published previously in abstract form (Gastroenterology 1982;82:1250).
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The authors thank Dawn Warren for secretarial assistance and Sandra Beaver and Roberta Jorgensen for serving as project coordinators for the PSC and PBC projects.