Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children*
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Cited by (76)
Comparison of intravenous ibuprofen pharmacokinetics between Caucasian and Chinese populations using physiologically based pharmacokinetics modeling and simulation
2023, European Journal of Pharmaceutical SciencesUse of physiologically based pharmacokinetic models coupled with pharmacodynamic models to assess the clinical relevance of current bioequivalence criteria for generic drug products containing ibuprofen
2014, Journal of Pharmaceutical SciencesCitation Excerpt :Despite the lack of statistical difference in these parameters between the two doses, the authors concluded that, based on three other AUC endpoints, including the AUC of the change in temperature required to reduce baseline to normal versus time (AUC ΔTempn), the 10-mg/kg dose was more effective. Nevertheless, when considering the low-temperature group, even AUC ΔTempn values were not significantly different between the two tested doses.27 Such apparent divergence between predicted and observed dose–response relationship might be because of the greater sample size in each simulated dose group than in the reported clinical trials as well as an underestimation of the variability in the simulations.
Dosing and antipyretic efficacy of oral acetaminophen in children
2013, Clinical TherapeuticsCitation Excerpt :Six studies used doses of <10 mg/kg; 9 studies, 10 mg/kg; 12 studies, >10–<15 mg/kg; 13 studies, 15 mg/kg; and 2 studies, 20–30 mg/kg. Table V17–57 additionally lists ΔTempmax by time following acetaminophen administration. Figure 3 shows mean ΔTemp for the 5 major dose ranges by time period following drug administration.
Regulatory review of acetaminophen clinical pharmacology in young pediatric patients
2012, Journal of Pharmaceutical SciencesCitation Excerpt :Studies with mean data only or with the lowest pediatric patient age of 2 years were not included. A total of 15 studies fit in this criteria and were included.33,38,42,43,45–55 The weighted sum of temperature reduction for 6 h (WSTD6) was calculated as the fever reduction endpoint.
FEVER: PATHOGENESIS AND TREATMENT
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth Edition
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Supported in part by Bristol-Myers Products, Hillside, N.J.
Presented in part at the XIth International Congress of Pharmacology, Amsterdam, The Netherlands, July 1–6, 1990.