Elsevier

The Journal of Pediatrics

Volume 116, Issue 2, February 1990, Pages 278-280
The Journal of Pediatrics

Clinical and laboratory observation
Natural history of premature thelarche in Olmsted County, Minnesota, 1940 to 1984*

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    However, this estimate reflects the sociomedical conditions of the early 1980s and was based on personal experience. In another study from the US, from 1940 to 1984 the crude incidence of precocious puberty was 3.5 per 100 000 person-years in girls between the ages of 6 months and 8 years in Olmsted County, Minnesota.24 That study investigated the incidence of precocious puberty by reviewing the medical records of girls with any diagnosis referable to breast development or other signs of sexual maturity that developed by the age of 8 years, and the diagnosis of precocious puberty was not confirmed based on hormonal studies such as the GnRH stimulation test.

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Supported in part by research grants AR-30582 and CA-36873 from the National Institutes of Health.

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