Fetal rubella pathology
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Cited by (100)
Rubella Virus
2018, Principles and Practice of Pediatric Infectious DiseasesInfectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management
2018, The Lancet Infectious DiseasesCitation Excerpt :The mechanisms by which rubella virus induces microcephaly remain largely unknown. Most human embryonic tissues can be infected by rubella virus54,65 and brain vessels have been found to degenerate following rubella infection.65–67 These observations suggest that a neurodegenerative mechanism could be a potential underlying cause of rubella-induced microcephaly in human beings.
Rubella Vaccines
2017, Plotkin's VaccinesImmunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome
2016, EBioMedicineCitation Excerpt :Congenital rubella syndrome (CRS) is a serious disease caused by RV infection in utero (Plotkin et al., 2011). During the period of maternal viremia, RV may infect the placenta, pass the placental barrier and enter the fetal bloodstream, possibly through emboli of necrotic endothelial cells originating from infected chorion (Tondury and Smith, 1966; Driscoll, 1969; Ornoy et al., 1973; Lima et al., 1977). If the fetus is infected during the first trimester of pregnancy, the virus usually persists until term in multiple fetal organs causing a spectrum of birth defects that includes hearing impairment, and ocular and cardiovascular abnormalities (Rawls, 1968; Singer et al., 1967; Esterly and Oppenheimer, 1973).
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Address, Department of Pediatrics, University of Wisconsin Medical Center, 1300 University Ave., Madison, Wis. 53706.
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Aided by a grant from the NationalFoundation, and by Research Career Development Award 5-K 3-HD-14-022-02