Renal failure in sick hypertensive premature infants receiving captopril therapy
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Cited by (96)
Neonatal Hypertension
2022, Clinics in PerinatologyCitation Excerpt :ACE inhibitors are one of the most common agents used in older children, but there are few data available regarding their use in neonates.68 In fact, neonates may be at higher risk for side effects from ACE inhibitors, with one case series describing prolonged, excessive hypotension with risk for acute kidney injury with oliguria unresponsive to fluid resuscitation in premature infants treated with captopril.69–71 Given their known effects on renal development in utero, there is also concern that there could be effects on ongoing postnatal renal development.
The hypertensive neonate
2020, Seminars in Fetal and Neonatal MedicineNeonatal Hypertension: Diagnosis and Management
2018, Nephrology and Fluid/Electrolyte Physiology: Neonatology Questions and ControversiesKidney Injury in the Neonate
2018, Nephrology and Fluid/Electrolyte Physiology: Neonatology Questions and ControversiesGlomerular Filtration Rate in Neonates
2018, Nephrology and Fluid/Electrolyte Physiology: Neonatology Questions and ControversiesCongenital Urinary Tract Obstruction: The Long View
2015, Advances in Chronic Kidney DiseaseCitation Excerpt :Angiotensin inhibitors have well-documented teratogenic effects on human kidney development and are strictly contraindicated in pregnancy.66 Moreover, angiotensin inhibition in the neonate can markedly reduce GFR and may impair kidney development, especially in the preterm infant or baby with kidney disease.67 Pharmacologic inhibition of angiotensin or genetic inactivation of multiple steps in the renin-angiotensin system in mice causes functional obstructive nephropathy and results in hydronephrosis and papillary atrophy.68
Supported in part by Nationai Institutes of Health grant GCRD NIH No. RR00036.