Original articlesRenal glucose reabsorption during hypertonic glucose infusion in female streptozotocin-induced diabetic rats
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Ursodeoxycholic acid decreases sodium-glucose cotransporter (SGLT2) expression and oxidative stress in the kidney of diabetic rats
2012, Diabetes Research and Clinical PracticeCitation Excerpt :During diabetes, hyperglycemia not only exposes the tubular structures from the basolateral side but also enhances the amounts of glucose filtered by the glomeruli and thereby increases the tubular glucose load, exposure, reabsorption and intracellular accumulation [1,14,15], this data are interesting, since hyperglycemia is also known to be associated with an increase in renal glucose uptake through transcellular glucose transporters [15]. In kidney from diabetic rats in both spontaneous and pharmacologically induced diabetes, the increased transtubular glucose flux was followed by an enhanced SGLT2 and GLUT2 expression [2–4,15–17]. Therefore, we evaluated the SGLT2 expression in cortex from diabetic rats.
Inhibition of renal glucose reabsorption: A novel strategy for achieving glucose control in type 2 diabetes mellitus
2008, Endocrine PracticeCitation Excerpt :Once the Tm is exceeded, however, glycosuria ensues. Studies in experimental animal models of diabetes (13-16) have reported an increased rate of glucose reab sorption in the proximal tubule in hyperglycemic diabetic rats due to increased gene expression and activity of both SGLT2 and GLUT2 (15-18). Similarly, in cultured human renal proximal tubular cells isolated from the urine of patients with type 2 diabetes, increased messenger RNA (mRNA) and protein expression, as well as enhanced transport activity of both SGLT2 and GLUT2, have been demonstrated (19) (Fig. 3).
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