Alendronate induces gastric injury and delays ulcer healing in rodents
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2016, European Journal of Pharmaceutics and BiopharmaceuticsAlendronate-calcium phosphate hybrid films promoted the osteoblast differentiation and inhibited osteoclastogenic activity
2015, Journal of Industrial and Engineering ChemistryCitation Excerpt :For the treatment of bone diseases, BPs are supplied via either oral administration or intravenous injection. These methods result in low absorption by body, less than 1–3% of administrated dosage [15], and can cause systemic side-effects including fever, throat or stomach ulcers [16,17]. In order to avoid unwanted side-effects while improving the efficacy of the drug, it will be desirable to develop alternate drug delivery systems which can maximize and sustain its effect while minimizing the drug dosage and side effects.
Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects
2013, Progress in Crystal Growth and Characterization of MaterialsCitation Excerpt :The classic BPs treatment is the systemic way by oral administration or intravenous injection. However, undesirable side-effects like fever [265], ulcers [266,267] or osteonecrosis of the jaw [267,268] are commonly observed by systemic use of BPs. Moreover low bioavailability is commonly observed for oral administration [269].
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2013, Acta MaterialiaRole of soluble guanylate cyclase activation in the gastroprotective effect of the HO-1/CO pathway against alendronate-induced gastric damage in rats
2013, European Journal of PharmacologyCitation Excerpt :Induction of phase II enzymes such as HO-1 renders cells more resistant to potential subsequent challenges of greater stress (Yeligar et al., 2010). In fact, alendronate has been shown to cause erosions and ulcers in rodents and human stomach and to interfere with the healing of pre-existing lesions (Elliott et al., 1998; Graham and Malaty, 1999; Wallace et al., 1999). The mechanism through which alendronate and other bisphosphonates cause mucosal injury has not been clearly identified.