Incremental area under response curve more accurately describes the triglyceride response to an oral fat load in both healthy and type 2 diabetic subjects☆
Section snippets
Materials and methods
Forty-seven type 2 diabetic patients, recruited from our outpatient clinic,20, 21 and 10 healthy medical students22 participated in studies concerning postprandial lipemia.
The type 2 diabetic patients had an average (mean ± SD) age of 65 ± 5 years, were overweight with a mean body mass index (BMI) of 28.2 ± 5.7 kg/m2, and had a mean hemoglobin A1c (HbA1c) of 7.2% ± 0.9 % (normal range, 3.5% to 5.5%). Fasting TG was 1.5 ± 0.7 mmol/L (range, 0.4 to 4.2 mmol/L). All patients been diagnosed with
Results
Basic plasma TG results from healthy subjects (20 test meals) and type 2 diabetic patients (82 test meals) are shown in Table 1.
Discussion
Our results strongly suggest that postprandial TG responses to an oral fat load should be calculated as the iAUC rather than the AUC in both healthy subjects and type 2 diabetic patients. Furthermore, the results of a simplified 3-point test were not equal to a more frequently sampled test in either healthy subjects or type 2 diabetic patients.
Our experiments were performed in a highly controlled setting, which minimized the variation of fasting TG,20, 21, 22 and the participants were given the
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Supported by grants from the Danish Research Council, Danish Diabetes Association, Institute of Experimental Clinical Research, Aarhus University, Eli Lilly Diabetes Research Foundation, The Novo Nordisk Foundation, The Novo Nordisk Research Foundation Committee, and Aage Louis-Hansens Mindefond.