Elsevier

Neuropsychologia

Volume 35, Issue 11, November 1997, Pages 1437-1444
Neuropsychologia

Neuroanatomical correlates of pleasant and unpleasant emotion

https://doi.org/10.1016/S0028-3932(97)00070-5Get rights and content

Abstract

Substantial evidence suggests that a key distinction in the classification of human emotion is that between an appetitive motivational system associated with positive or pleasant emotion and an aversive motivational system associated with negative or unpleasant emotion. To explore the neural substrates of these two systems, 12 healthy women viewed sets of pictures previously demonstrated to elicit pleasant, unpleasant and neutral emotion, while positron emission tomographic (PET) measurements of regional cerebral blood flow were obtained. Pleasant and unpleasant emotions were each distinguished from neutral emotion conditions by significantly increased cerebral blood flow in the vicinity of the medial prefrontal cortex (Brodmann's area 9), thalamus, hypothalamus and midbrain (P<0.005). Unpleasant was distinguished from neutral or pleasant emotion by activation of the bilateral occipito-temporal cortex and cerebellum, and left parahippocampal gyrus, hippocampus and amygdala (P<0.005). Pleasant was also distinguished from neutral but not unpleasant emotion by activation of the head of the left caudate nucleus (P<0.005). These findings are consistent with those from other recent PET studies of human emotion and demonstrate that there are both common and unique components of the neural networks mediating pleasant and unpleasant emotion in healthy women.

References (53)

  • D.G. Amaral et al.

    Anatomical organization of the primate amygdaloid complex

  • P. Bard

    A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system

    American Journal of Physiology

    (1928)
  • W.B. Cannon

    Bodily Changes in Pain, Hunger, Fear and Rage

    (1929)
  • D.L. Collins et al.

    Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space

    Journal of Computer Assisted Tomography

    (1994)
  • A.R. Damasio

    Descartes' Error

    (1994)
  • R.J. Davidson et al.

    Approach/withdrawal and cerebral asymmetry: emotional expression and brain physiology, I

    Journal of Personality and Social Psychology

    (1990)
  • M. Davis

    Neural systems involved in fear-potentiated startle

    Annals of the New York Academy of Sciences

    (1989)
  • O. Devinsky et al.

    Contributions of anterior cingulate cortex to behavior

    Brain

    (1995)
  • A. Dickinson et al.

    Appetitive-aversive interactions and inhibitory processes

  • B.J. Everitt et al.

    Amygdala-ventral striatal interactions and reward-related process

  • M. Fredrikson et al.

    Functional neuroanatomy of visually elicited simple phobic fear: additional data and theoretical analysis

    Psychophysiology

    (1995)
  • K. Friston et al.

    The relationship between global and local changes in PET scans

    Journal of Cerebral Blood Flow and Metabolism

    (1990)
  • K.J. Friston et al.

    Comparing functional (PET) images: the assessment of significant change

    Journal of Cerebral Blood Flow and Metabolism

    (1991)
  • M.S. George et al.

    Brain activity during transient sadness and happiness in healthy women

    American Journal of Psychiatry

    (1995)
  • W. Irwin et al.

    Human amygdala activation detected with echo-planar functional magnetic resonance imaging

    NeuroReport

    (1996)
  • T.A. Ketter et al.

    Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences

    Archives of General Psychiatry

    (1996)
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