Goniothalamin and its distribution in four Goniothalamus species
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Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro
2019, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :Fraction 40 from each Cn-L and Cn-R elicited a significant (P < 0.0001) inhibition of L4 development (Fig. 1), and fractions 41–42 and 44–45 from Pm-R displayed the most significant (P < 0.0001) developmental inhibition (Fig. 1). The NMR and MS analyses of fraction 40 of each Cn-L and Cn-R revealed pure goniothalamin (GNT; 27.4–31.3 mg, 0.86–0.98% dry weight) (Supplementary File 1; cf. Jewers et al., 1972). Separate analyses of fractions 41 and 42 of Pm-R revealed dihydrokavain (DHK; 6.9 mg, 0.43% dry weight) (Supplementary File 1; cf. Dharmaratne et al., 2002) in both fractions.
Asymmetric synthesis of (-)-leiocarpin A via (-)-(S)-goniothalamin employing Julia-Kocienski olefination
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