Randomized controlled trials in surgery: Issues and problems
References (13)
- et al.
Should we be performing more randomized controlled trials evaluating surgical operations?
Surgery
(1995) Are clinical trials a cost-effective investment?
JAMA
(1989)Equipoise and the ethics of clinical research
N Engl J Med
(1987)- et al.
Physicians' reasons for not entering eligible patients in a randomized clinical trial of adjuvant surgery for breast cancer
N Engl J Med
(1984) - et al.
Fundamentals of clinical trials
(1985)
Cited by (121)
Modelling the cost-effectiveness of total knee arthroplasty: A systematic review
2020, Journal of OrthopaedicsCitation Excerpt :This is important as higher levels of evidence are more convincing to surgeons when tackling clinical dilemmas18 such as the ones in question here. However, it is important to acknowledge that since RCTs are not always possible,19 Level-I evidence may not be available for all clinical scenarios and Level-III or IV evidence may still be of great value to orthopaedic surgeons. Another important finding is that 54.5% (n = 18) CEAs used exclusively a healthcare perspective in order to derive the costs.
Comparison of safety and utilization outcomes in inpatient versus outpatient laparoscopic sleeve gastrectomy: a retrospective, cohort study
2020, Surgery for Obesity and Related DiseasesA systematic review and meta-analysis of the clinical outcomes for various surgical modalities in the management of temporomandibular joint ankylosis
2015, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :Several obstacles have been proposed to explain the paucity of randomized trials and other high-quality prospective study designs. These include the rarity of many surgical conditions, diminishing funding in support of clinical trials, difficulty with standardizing surgical procedures, surgeon preference for specific operations, and the reluctance of patients to assign their children randomly to a potentially invasive treatment arm, among others.75–82 Although no significant publication bias was observed using funnel plots, it is still feasible that negative or null findings from studies were not published, leading to publication bias and possibly accounting for the small number of studies in this review.
Statistical issues in randomised controlled trials: A narrative synthesis
2015, Asian Pacific Journal of Tropical Biomedicine
- 1
Dr. Wright is supported by a Medical Research Council Scholarship
- 2
Dr. Solomon is a Fellow in Clinical Epidemiology supported by the Jenour Foundation, Australia; Samuel Lunenfeld Mount Sinai Research Institute; and Ethicon Canada.