Transplantation of human hepatocytes
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Cited by (153)
Cell Transplantation
2020, Pediatric Liver TransplantationAssessment of animal experimental models of toxic liver injury in the context of their potential application as preclinical models for cell therapy
2019, European Journal of PharmacologyCitation Excerpt :Initially autologous hepatocytes were isolated and reinfused in patients affected by end-stage cirrhosis, resulting in poor and extremely limited outcomes (Mito et al., 1992). Simultaneously, another group used allogenic donor cells to provide subsistence to patients with fulminant hepatitis (Strom et al., 1997). Such approach proved to be efficient and safe, since donor hepatocytes were able to provide support of metabolic and synthetic liver functions while the native liver regenerated.
In vitro and in vivo translational models for rare liver diseases
2019, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The selective advantage for FAH+ hepatocytes also led to an FAH mouse with a “humanized” liver. An FRG immune deficient null mouse model, Fah−/−/Rag2−/−/IL2rg−/− was repopulated with human FAH+ hepatocytes [83, 84]. Even though the mouse has answered many questions and recapitulates many aspect of the human liver disease, there are limitations, and the model is missing a critical phenotype of the disease, cirrhosis.
Hepatocyte transplantation: past efforts, current technology, and future expansion of therapeutic potential
2018, Journal of Surgical ResearchCitation Excerpt :Another study evaluated autologous transfers with some success as demonstrated by a reduction in ammonia levels. Unlike the other previously described conditions, A1AD with time leads to parenchymal damage, which complicates potential cell engraftment due to destruction of the innate liver structure.11 Other conditions that have been evaluated with similar results include glycogen storage diseases, urea cycle disorders, and factor VII deficiency.12,13
Cell Therapy of Liver Disease
2018, Principles of Regenerative MedicineStem Cells and Hepatocyte Transplantation
2017, Zakim and Boyer's Hepatology: A Textbook of Liver Disease