Original ArticlesThe nature of ischemia/reperfusion injury
Section snippets
Ischemia/reperfusion injury: its definition, nature, and biological significance in the microcirculation
The transplantation of a vascularized organ requires the discontinuation of the organ blood supply. Hence, any solid organ graft undergoes by definition damage due to ischemia/reperfusion (I/R). Apart from rejection-related events, the manifestation of I/R injury, therefore, is a serious issue in organ transplantation, bearing the potential to shorten graft and patient survival.
I/R injury in experimental small bowel transplantation
Clinical small bowel transplantation (SBT) has been advocated for patients with short bowel syndrome in the case that long-term parenteral nutrition is not a viable option. However, a major problem hampering SBT is the manifestation of I/R injury. Besides threatening graft function and graft survival, microvascular reperfusion injury aggravates the processes of acute and chronic rejection.73 Thus, prevention of postischemic microvascular injury following SBT is of pivotal interest.
The available
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2017, Transplantation ProceedingsCitation Excerpt :Prospective, randomized, controlled studies are needed to demonstrate causative nature of this association. Ischemia-reperfusion injury (IRI) is tissue damage caused by anoxic and hypoxic injuries during ischemia followed by inflammatory damage during reperfusion [46]. IRI is a non-immunologic cause of endothelial injury that can lead to vasculopathy [47], which has been shown in a rodent model [48].
Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling
2016, Journal of Ayurveda and Integrative MedicineCitation Excerpt :In humans, thrombosis of the mesenteric venous vessels can result in haemorrhagic infarction with acute mesenteric ischaemia and irreversible severe tissue pathology [16–18]. Complex interactions between the endothelium and several cell types can be provoked by ischaemia-reperfusion with resultant microvascular injury, cellular necrosis and/or apoptosis [19–21]. In severe conditions, resulting inflammatory responses from ischaemia-reperfusion injury may lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) [22,23].
Protective effect of ischemic preconditioning on the jejunal graft mucosa injury during cold preservation
2015, Experimental and Molecular PathologyAnti-inflammatory effects of ischemic preconditioning on rat small bowel allografts
2014, Transplantation ProceedingsAnti-thymocyte gamma-globulin may prevent antibody production after heart transplantation
2014, Transplantation ProceedingsCitation Excerpt :The clinical benefits of RATG may also go beyond its immunomodulatory effects of the adaptive alloimmune response and provide protection from the activation of the innate immune response through ischemia-reperfusion injury. Ischemia-reperfusion injury involves a cascade of events in which endothelial cells are initially injured by temporary ischemia, tissue hypoxia, and toxic metabolites followed by immunologic damage from reperfusion [22]. The expression of cell surface adhesion molecules through endothelial cell activation triggers the migration of inflammatory cytokines that induce cytotoxic effects in the reperfused tissue [23].