Cell biology of endothelial cells
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2021, eClinicalMedicineCitation Excerpt :In addition, the significance of microvascular damage is highlighted by other markers of endothelial cell activation and angiogenesis, the presence of circulating endothelial cells, and an association of endothelium activation with disease severity including respiratory and multiorgan failure [10–15,11–13,61,63]. Moreover, it is congruent with a pathologic process affecting endothelial cells given the vast surface it occupies estimated in more than 1000 m2, or 1012 endothelial cells (there are ∼ 1010 blood monocytes) weighting in excess of 100 gs in the adult human [64]. Neutrophils have a critical role in immunothrombosis through interaction with activated endothelial cells, and release of NETs [21–27].
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Received from the Division of Hematology-Oncology, Department of Medicine, Cornell University Medical College, New York, New York