Original contributionProliferative activities in conventional chordoma: A Clinicopathologic, DNA flow cytometric, and immunohistochemical analysis of 17 specimens with special reference to anaplastic chordoma showing a diffuse proliferation and nuclear atypia☆
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Cited by (41)
The Degree of Middle and Lower Clivus Invasion by Chordoma is Linked to Patient Prognosis Via Ki-67 Value
2019, World NeurosurgeryCitation Excerpt :Additional factors related to the chordoma prognosis have been reported in previous studies, including the growth and invasion site of the tumor, the deletion and acquisition of genes, and the misregulation of related genes. The proliferative ability of skull-base chordomas seems to be closely related to recurrence and nuclear pleomorphism,20 and correlates with the combination of p53 overexpression, abnormal proliferation, high heteromorphism, and diffuse proliferation.21 Mutation of p53 can also lead to an increased probability of recurrence.
Recurrent skull base chordomas: Role of surgery
2018, Chordomas and Chondrosarcomas of the Skull Base and SpinePathology of chordoma and chondrosarcoma of the axial skeleton
2018, Chordomas and Chondrosarcomas of the Skull Base and SpineChordoma: The entity
2014, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :DNA sequencing of the full p53 gene would clarify such ambiguity, but to date has not been reported. However, data concerning p53 protein overexpression are available but varying expression has been reported between 0% and 53% [117,122–127]. Even though all of the studies are based on immohistochemical techniques, the discrepancy in outcome might be explained by the use of semi-qualitative versus quantitative methods of analysis, and by differences in interpretations (cut-off points) of the data.
A Comparison of Cell-Cycle Markers in Skull Base and Sacral Chordomas
2014, World NeurosurgeryCitation Excerpt :MDM2 expression is also controlled by p53 transcription, making it a negative feedback regulatory system (22). In chordoma, inconsistent p53 overexpression has been reported by several authors (15, 18, 23, 28, 30, 33, 37), but is shown to be well correlated with a high MIB-1 labeling index (LI), a proliferation index using the expression of the Ki-67 protein (23, 28, 30, 33, 37). Excess p53 protein, in addition, generally is associated with a worse clinical outcome.
Skull Base Chordomas. Clinical Features, Prognostic Factors, and Therapeutics.
2013, Neurosurgery Clinics of North AmericaCitation Excerpt :Other factors believed to influence prognosis include the classic and chondroid histology (better prognosis compared with dedifferentiated variant), the presence of necrosis and mitotic figures (poor prognosis), metastases (poor prognosis), larger tumor volume at diagnosis (prognostic factor for tumor recurrence and poor prognosis), and Ki67-positive staining (poor prognosis).5,7,102 Additional molecular expression marker studies have identified MIB-I, p53, and cyclin D1 as potential predictors of recurrence and prognosis, citing that the proliferative potential of chordomas may be correlated with the combination of p53 overexpression, anaplasia, and high-grade atypia.103,104 Skull base chordomas are exceptionally rare tumors that grow in the clivus, often presenting with CN palsies, headache, and visual field cuts.
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Supported in part by Grants in Aid for Scientific Research (grant nos. 06280105 and 06280115) from the Ministry of Education, Science and Culture, Japan.