Osteoarthritis in ankle and knee joints*
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2021, FootCitation Excerpt :In fact, these inflammatory cytokines and matrix metalloproteinases have been shown to play a role in cartilage damage that can be observed after only 10 days post-fracture [9]. Longer term, these same inflammatory mediators have been shown to persist in the ankle microenvironment at 6 months post-operatively, well beyond fracture healing, which suggests they continue to play a role in the development of post-traumatic osteoarthritis, which is higher in the ankle than the other major lower extremity joints [10,11,27]. There is also evidence that blocking the inflammatory process after closed fracture in mouse models can reduce post-traumatic arthritis [28].
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Supported by NIH grant 2-P50-AR-39239 and German Academic Exchange Service (DAAD-Fellowship, KH.).