Elsevier

Advances in Immunology

Volume 33, 1982, Pages 241-306
Advances in Immunology

The Biochemistry and Pathophysiology of the Contact System of Plasma1

https://doi.org/10.1016/S0065-2776(08)60837-8Get rights and content

Publisher Summary

Plasma proteins form major transport systems as in the case of lipoproteins and iron-binding proteins or recognition systems as in the case of immunoglobulins; and they play important roles in the defense of the organism. In addition to the immunoglobulins, four major pathways of proteins in the plasma contribute to the host's capacity to defend against foreign substances, traumatic events, and internal disorders: they are the complement, contact (Hageman factor), extrinsic clotting, and fibrinolytic systems. These four systems have the capacity to act in concert and cross-activate one another. They may function as a direct or indirect consequence of immunologic activity. The investigations of the past 10 years have already shed considerable light on the interactions of proteins with surfaces and with other protein molecules and in the cascading conversion of proenzymes to their activated form. Inroads have also been made into the pathologic implications of the contact system when set into motion. In its most condensed form, the contact system consists of four proteins: Hageman factor (HF), prekallikrein, high-molecular-weight (MW) kininogen, and coagulation Factor XI. However, several other proteins may be involved.

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    This is publication No. 1973 from the Research Institute of Scripps Clinic.

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