Proteases of Protozoan Parasites
References (317)
- et al.
Endoprotease in Plasmodium yoelii nigeriensis
Comparative Biochemistry and Physiology
(1983) Characterisation of an alkaline peptidase of Trypanosoma cruzi and other trypanosomatids
Molecular and Biochemical Parasitology
(1990)- et al.
Lysis of trypanosomes by peptidyl fluoromethyl ketones
Biochemical and Biophysical Research Communications
(1990) - et al.
Substrate specificity and inhibitor sensitivity of a trypanosomatid alkaline peptidase
Biochimica et Biophysica Acta
(1990) - et al.
Estimation of population at risk of infection and number of cases of leishmaniasis
Parasitology Today
(1992) - et al.
The C-terminal extension of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi
Molecular and Biochemical Parasitology
(1991) - et al.
Entamoeba histolytica trophozoites: a surface-associated cysteine protease
Experimental Parasitology
(1993) - et al.
Plasmodium falciparum: isolation and characterization of a 55-kDa protease with a cathepsin D-like activity from P. falciparum
Experimental Parasitology
(1991) - et al.
Studies on malarial parasites. IX. Chemical and metabolic changes during growth and multiplication in vivo and in vitro
Journal of Biological Chemistry
(1948) Classification of peptidases
Methods in Enzymology
(1994)
Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase
Molecular and Biochemical Parasitology
Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana
Molecular and Biochemical Parasitology
Alignment/phylogeny of the papain superfamily of cysteine proteases
Journal of Molecular Biology
Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion
Molecular and Biochemical Parasitology
A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-1
Molecular and Biochemical Parasitology
Characterization and expression of proteases during Trypanosoma cruzi metacyclogenesis
Experimental Parasitology
Subcellular localization of a cysteine proteinase from Trypanosoma cruzi
Molecular and Biochemical Parasitology
Identification and purification of membrane and soluble forms of the major surface protein of Leishmania promastigotes
Journal of Biological Chemistry
Identification of the promastigote surface protease in seven species of Leishmania
Molecular and Biochemical Parasitology
Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase
Molecular and Biochemical Parasitology
Leishmanolysin: surface metalloproteinase of Leishmania
Methods in Enzymology
Matrix metalloproteinase inhibition: a review of anti-tumour activity
Annals of Oncology
A 120-kDa alkaline peptidase from Trypanosoma cruzi is involved in the generation of a novel Ca(2+)-signaling factor for mammalian cells
Journal of Biological Chemistry
Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed
Molecular and Biochemical Parasitology
Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinase
Gene
Amino acid sequence of the serine-repeat antigen (SERA) of Plasmodium falciparum determined from cloned cDNA
Molecular and Biochemical Parasitology
A major cysteine proteinase is developmentally regulated in Trypanosoma cruzi
FEMS Microbiology Letters
The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes
Molecular and Biochemical Parasitology
Further characterization and partial amino acid sequence of a cysteine proteinase from Trypanosoma cruzi
Molecular and Biochemical Parasitology
Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi
Biochimica et Biophysica Acta
Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes
Molecular and Biochemical Parasitology
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages
Journal of Biological Chemistry
Giardia muris: ultrastructural analysis of in vitro excystation
Experimental Parasitology
Membrane-associated proteases process Plasmodium falciparum merozoite surface antigen-1 (MSA1) to fragment gp41
Molecular and Biochemical Parasitology
Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum
Molecular and Biochemical Parasitology
Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum
Molecular and Biochemical Parasitology
Purification and characterization of 37-kilodalton proteases from Plasmodium falciparum and Plasmodium berghei which cleave erythrocyte cytoskeletal components
Molecular and Biochemical Parasitology
Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi
Journal of Biological Chemistry
Localization, biosynthesis, processing and isolation of a major 126 kDa antigen of the parasitophorous vacuole of Plasmodium falciparum
Molecular and Biochemical Parasitology
Plasmodium falciparum: protease inhibitors and inhibition of erythrocyte invasion
Experimental Parasitology
Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites
Molecular and Biochemical Parasitology
The sequence, organization and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi
Journal of Biological Chemistry
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi
Journal of Biological Chemistry
African trypanosomes have differentially expressed genes encoding homologues of the leishmania GP63 surface protease
Journal of Biological Chemistry
Identification of a surface metalloproteinase on 13 species of Leishmania isolated from humans, Crithidia fasciculata and Herpetomonas samuelpessoai
Acta Tropica
Characterization of native falcipain, an enzyme involved in Plasmodium falciparum haemoglobin degradation
Molecular and Biochemical Parasitology
Biosynthesis and maturation of the malaria aspartic haemoglobinases plasmepsins I and II
Journal of Biological Chemistry
Effects of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi
FEMS Microbiology Letters
The major surface glycoprotein (GP63) is present in both life stages of Leishmania
Molecular and Biochemical Parasitology
An investigation into the significance of the N-linked oligosaccharides of Leishmania gp63
Molecular and Biochemical Parasitology
Cited by (104)
Expression and secretion of the Giardia duodenalis variant surface protein 9B10A by transfected trophozoites causes damage to epithelial cell monolayers mediated by protease activity
2017, Experimental ParasitologyCitation Excerpt :In this context the VSP9B10A protein would be the first VSP protein of Giardia identified as a pathogenicity factor causing damage to the integrity of epithelial cell monolayers, hence it is important to determine the molecular mechanisms involved in the damage observed in the epithelial cells. Regarding the role of the VSP9B10A protein in the host-parasite interaction, it has been observed that cysteine proteinases in many parasites are critical in the parasite's life cycle and pathogenic processes like adhesion, cyto-adherence, immune evasion, enzyme activation, virulence, tissue invasion, encystation, excystation, hatching and molting (McKerrow, 1989; McKerrow et al., 2006; PiƱa-Vazquez et al., 2012; Rosenthal, 1999). In parasites like Plasmodium falciparum, or bacteria Neisseria gonorrhea and Borrelia hermsii exist a family of genes similar to vsp that encode proteins that are involved in adherence to host cells, the onset of several symptoms of Malaria and the variation in the expression from one var gene to another can change the adhesion characteristics of these parasites (Lanzer et al., 1995; Nielsen et al., 2002).
Immunity against selected piscine flagellates
2014, Developmental and Comparative ImmunologyLeishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates
2012, Molecular and Biochemical ParasitologyCitation Excerpt :Peptidases are critical for the survival and pathogenicity of parasites, playing roles in the recycling and metabolism of proteins [1ā6], invasion of host cells and tissues [7,8], parasite nutrition, modification of host proteins [8,9], parasite immune evasion and differentiation [10ā12].
Representational difference analysis identifies specific genes in the interaction of Giardia duodenalis with the murine intestinal epithelial cell line, IEC-6
2012, International Journal for ParasitologyCryptic Parasite Revealed. Improved Prospects for Treatment and Control of Human Cryptosporidiosis Through Advanced Technologies <sup>{star operator}</sup>
2011, Advances in ParasitologyCitation Excerpt :In brief, an infective dosage of sporulated oocysts (containing four naked, sporozoites) is ingested by the host. Upon encountering specific environmental cues, which, for C. parvum and C. hominis, appear to include salt (particularly bile salt) concentration, pH and temperature (Smith et al., 2005a), the oocysts excyst in the small intestine; this process appears to involve the activation of several serine proteases (Rosenthal, 1999). Upon excystation, each sporozoite migrates along the gut epithelium (e.g. microvilli of enterocytes in the small intestine) by gliding motility, āpoweredā by an intracellular actinomyosin motor (Forney et al., 1998; Wetzel et al., 2005).