“Perestroika” in the basal forebrain: Opening the border between neurology and psychiatry

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This chapter focuses on recent advances in the understanding of basal forebrain organization. Such knowledge forms the necessary conceptual framework for physiologic, behavioral, and clinical studies of forebrain functions relevant to neuropsychiatric disorders. Description of the anatomy of the basal forebrain has touched only peripherally on closely related areas of septal and hypothalamic neuronal systems or the many aspects of diffuse ascending brainstem projections. Nevertheless, considering the strategic position of the three basal forebrain systems discussed in the chapter, and the intimate relation that they have with one another and with other parts of the neuraxis, it is not difficult to envision how disruption of the functional integrity of any one of these systems can easily present itself with a multitude of symptoms that show little regard for traditional boundaries of neurologic and psychiatric disciplines.

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    Instituto de Investigation Medica, Cordoba, Argentina

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