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BRCA1/2-related ovarian cancers are of tubal origin: a hypothesis

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    After a breast cancer diagnosis, risk-reducing salpingo-oophorectomy for breast cancer mortality reduction should be considered within 2 years to BRCA1 carriers, and for BRCA2 carriers as part of their breast cancer treatment if considered appropriate by their oncologist (strong, high). There is a mounting body of evidence to support a precursor lesion of serous carcinoma in the fimbrial ends of the fallopian tubes.60,61 Pathologic studies obtained from BRCA1/2 mutation carriers undergoing prophylactic RRSO surgery have demonstrated high-grade serous intraepithelial precursor lesions/carcinomas in the fimbria: these lesions have been associated with an increased risk of peritoneal cancer.62–64

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