Molecular characterization of dog albumin as a cross-reactive allergen☆,☆☆,★,★★
Section snippets
Characterization of allergic patients' sera
Sera from 110 patients were selected for this study according to case history, positive skin prick test results and positive RAST results, as described by Jarolim et al. 21 All patients showed reactivity to other allergens (e.g., tree pollen, grass pollen, mite, cat and horse dander, guinea pig epithelia). Sera from 22 healthy persons with a negative case history of any type I allergy and negative skin prick test and RAST results to dog allergens were pooled (normal human serum pool) and used
Determination of the percentage of patients allergic to dog albumin
DISCUSSION
Type I allergies to mammalian proteins, in particular to dog and cat allergens, are frequently related. 17, 18, 19 Although the major dog allergens Can f I 7, 13 and Can f II 7, 14 and the major cat allergen Fel d I 15, 16 show similar molecular weights, these allergens are neither immunologically nor structurally related. However, albumin was identified as a relevant IgE-binding structure in dog and cat hair/dander extracts. 7, 12, 20 About 35% of patients allergic to dogs display IgE
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Cited by (0)
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From aInstitute of Medical and Chemical Laboratory Diagnostics; bDepartment of Hematology and Hemostaseology; c Institute of General and Experimental Pathology, AKH, University of Vienna, Austria.
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Supported by grants S06703 and S06712-Med of the “Fonds zur Förderung der wissenschaftlichen Forschung and grant 3/8603 of the “Fonds zur Förderung der gewerblichen Wirtschaft,” Vienna, Austria.
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Reprint requests: Rudolf Valenta, MD, Institute of General and Experimental Pathology, AKH, University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.
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