Pulpal changes in replanted and autotransplanted immature teeth of dogs
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2023, Journal of Oral BiosciencesCan delayed grafting of frozen teeth achieve periodontal ligament healing?
2022, Medical HypothesesCitation Excerpt :Dental experts are also trying to apply the cryopreservation to the tooth, which includes tooth germ preservation, pulp preservation, and PDL preservation. The advantages and disadvantages of cryopreservation are well known: [16] (i) tooth germ could erupt normally after freezing, but the roots’ malformation and number were abnormal; (ii)PDL might regenerate after freezing but the time was relatively lagging behind, even with tendency of inflammatory reaction and root resorption [17,18]; (iii)Most regeneration of pulp tissue after freezing occurred in young permanent teeth, which means it was highly dependent on apical foramen size due to blocked diffusion of cryoprotectants [19]. Although the negative effects of freezing include osmotic and mechanical damage, oxidative stress (OS) and toxic damage by cryoprotectants (CPAs) [20], deep hypothermia still remains the most effective way to preserve cells.
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This study as supported by grants from the Faculty of Octontology, University of Lund.
- 1
Dr. Skoglund is research associate, department of oral surgery, School of Dentistry, University of Lund, Malmö, Sweden.
- 2
Dr. Tronstad is professor and chairman, department of endodontics, Universty of Pennsylvania, School of Dental Medicine, Philadelphia.