Preliminary CommunicationOXIDATIVE ENZYMES AND PHOSPHORYLASE IN CENTRAL-CORE DISEASE OF MUSCLE
References (1)
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Brain
(1956)
Cited by (82)
A brief history of the congenital myopathies – the myopathological perspective
2023, Neuromuscular DisordersHistorical aspects of muscle research in the Dubowitz Neuromuscular Centre: the Hammersmith days
2021, Neuromuscular DisordersCitation Excerpt :Victor had worked with Pearse in the 50′s when he became interested in muscle pathology and wanted to learn more about enzyme histochemistry. That collaboration produced two important papers one demonstrating the reciprocal activity of oxidative enzymes and phosphorylase in type I and type II fibres [1] and the other demonstrating the absence of both oxidative enzymes and phosphorylase in cores [2]. ( Cores do not contain glycogen and the staining method used to demonstrate phosphorylase requires endogenous glycogen, which probably explains the absence of phosphorylase in cores).
A review of core myopathy: central core disease, multiminicore disease, dusty core disease, and core-rod myopathy
2021, Neuromuscular DisordersCitation Excerpt :In 1956, Shy and Magee first reported dominantly inherited non-progressive congenital myopathy in a family with anatomical changes observed in the central fibrils using Gomori trichrome staining [4]. Later, Dubowitz and Pearse found that enzyme histochemistry, including phosphorylase and oxidative enzyme staining, can reveal muscle fiber type as well as define central cores [1,29]. Typical CCD shows extreme type 1 fiber predominance with only a few type 2 fibers or even none at all, which is sometimes termed “uniform type 1 fiber.”
Calcium channels linked to altered cellular function and disease
2020, Current Opinion in PhysiologyCitation Excerpt :The estimated prevalence for congenital myopathies is 1:26 000 in the pediatric population [37]. Central cores are areas in the cytoplasm of muscle fibers which show reduced oxidative and mitochondrial staining [18••,38,39]. CCD is associated with dominantly or recessively inherited mutations in the RYR1 gene [29,40].
Congenital Myopathies and Related Disorders
2013, Muscle Biopsy: A Practical Approach Expert Consult; Online and PrintHistological and Histochemical changes
2013, Muscle Biopsy: A Practical Approach Expert Consult; Online and Print