Elsevier

The Lancet

Volume 298, Issue 7719, 7 August 1971, Pages 283-287
The Lancet

ORIGINAL ARTICLES
VITAMIN-D DEFICIENCY AND PRIMARY HYPERPARATHYROIDISM

https://doi.org/10.1016/S0140-6736(71)91333-XGet rights and content

Abstract

Two patients with normocalcæmic primary hyperparathyroidism are reported. One patient had severe osteitis fibrosa cystica. Small doses of vitamin D were given to both patients for 11 and 16 months: raised serum-alkalinephosphatase levels returned to normal, remineralisation of bone occurred, and the subperiosteal cortical bone erosions healed. It is suggested that vitamin D deficiency is responsible for the development of bone disease in some patients with hyperparathyroidism. There may be an increased requirement for vitamin D in this disorder.

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