Elsevier

The Lancet

Volume 303, Issue 7870, 29 June 1974, Pages 1313-1316
The Lancet

DRUG-CARRIER POTENTIAL OF LIPOSOMES IN CANCER CHEMOTHERAPY

https://doi.org/10.1016/S0140-6736(74)90682-5Get rights and content

Abstract

The possibility of using liposomes as carriers of drugs has been investigated in three patients with metastatic cancer. The fate of liposomes injected into the circulation was followed by the removal from plasma and uptake of entrapped tracer-labelled albumin by the tissues, and by electron-microscopic observations of the localisation of liposome carrier within normal and malignant cells. With most organs a degree of preferential uptake of radioactivity was observed in the malignant deposits.

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