Preliminary CommunicationsIN-VITRO SYNTHESIS OF ANTI-ACETYLCHOLINE-RECEPTOR ANTIBODY BY THYMIC LYMPHOCYTES IN MYASTHENIA GRAVIS
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Myasthenia gravis and related disorders
2019, The Autoimmune DiseasesAnterior mediastinal tissue volume is correlated with antiacetylcholine receptor antibody level in myasthenia gravis
2018, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :V−30 was also strongly correlated with the histologic volume, which supports the reliability of V−30 as a reflection of the actual thymus volume. The ability to produce AChRAb in the thymus is the basis for choice of extended thymectomy for MG, although it is appropriate to regard MG as a systemic disease because other sites may also produce AChRAb.23,24 Establishment of the volume of the lesion associated with MG or the thymic contribution to MG may help to determine treatment strategy for MG and to elucidate the etiology of MG.
Thymus involvement in myasthenia gravis: Epidemiological and clinical impacts of different self-tolerance breakdown mechanisms
2016, Journal of NeuroimmunologyMyasthenia Gravis
2016, Encyclopedia of ImmunobiologyClonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor
2014, Journal of AutoimmunityCitation Excerpt :This heterogeneity implies a polyclonal response of thymic B cells to various antigens. Such specificities have previously been documented among thymic MG B cells for tetanus toxoid [19], influenza virus [17,56] and striational muscle antigens upon stimulation with pokeweed mitogen (PWM) [39]. In contrast, AChR antibody production is rarely increased by PWM stimulation [29].