ENTEROHEPATIC CIRCULATION OF VITAMIN D: A REAPPRAISAL OF THE HYPOTHESIS
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2021, Journal of Clinical DensitometryCitation Excerpt :According to the latest data, 22%–70% of patients with Crohn's disease and about 45% of those with ulcerative colitis suffer from vitamin D deficiency (13). The main causes of inflammatory bowel diseases are considered to be: decreased exposition to sunlight (14), inappropriate diet, inflammatory changes in the bowel mucosa, and consequences of the digestive tract resection (15,16). This leads to osteomalacia (defective bone mineralization with the maintenance of the normal bone mass) and osteoporosis (a decrease of the properly mineralized bone mass).
Impact of co-administration of protonated nanostructured aluminum silicate (cholesterol absorption inhibitor) on the absorption of lipid soluble vitamins D<inf>3</inf> and K<inf>1</inf>: An assessment of pharmacokinetic and in vitro intraluminal processing
2013, European Journal of Pharmaceutical SciencesCitation Excerpt :The appearance of a peak following intravenous injection was previously reported for vitamin D3 (Ponchon and DeLuca, 1969), clonazepam (Crevoisier et al., 2003) and baicalein (Xing et al., 2005) which could be due to enterohepatic circulation following oral and/or intravenous administration. Both vitamins D3 and K1 undergo enterohepatic circulation and this phenomenon could contribute to the appearance of the double peaks in the plasma profiles following oral administration (Clements et al., 1984; Gopakumar et al., 2010). Following oral administration, vitamin D3 had lower peak concentrations (Cmax) in the presence of NSAS slurry and NSAS-fortified diet when compared to the control group.
Influence of ileal pouch anal anastomosis on bone loss in ulcerative colitis patients
2011, Journal of Crohn's and ColitisCitation Excerpt :Further, low BMD might be related to potential adverse metabolic consequences of pouch surgery. Bacterial overload in the ileal pouch may lead to the deconjugation of bile acids,31–33 impairing their reabsorption, which may theoretically cause malabsorption of vitamin D.34 However, vitamin D deficiency alone is not the cause of low BMD,11 although osteomalacia and vitamin D deficiency are not uncommon in IBD.1 An abnormal metabolism of vitamin K in IPAA patients may be also associated with a low bone mass.23
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