MALIGNANT HISTIOCYTOSIS OF THE INTESTINE: A T-CELL LYMPHOMA
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Primary gastrointestinal T-cell lymphomas: concepts and diagnostic insights
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2012, BloodCitation Excerpt :A PCR analysis indicative for a monoclonal rearrangement of the TCR-γ chain on intestinal tissue sections and an immunohistochemical or flow cytometric characterization of IELs indicative for an aberrant T-cell population have a high predictive value in identifying the progression of RCD into EATL48 and therefore can be of help in the diagnostic workup before an overt lymphoma has developed. Among the methods used to detect monoclonal rearrangement of TCR-γ genes, PCR has the advantage that it can be applied to formalin-fixed, paraffin-embedded specimens,49 unlike Southern blotting on extracted DNA, which requires fresh frozen tissue.50 TCR-γ clonal amplification has been identified in the duodenal biopsies of patients with RCD2 and UJI as in the subsequent tumor specimens.51,52
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