INFANTS BORN TO MOTHERS SEROPOSITIVE FOR HUMAN IMMUNODEFICIENCY VIRUS: Preliminary Findings from a Multicentre European Study

doi:10.1016/S0140-6736(87)92142-8

The Lancet

Volume 329, Issue 8543, 23 May 1987, Pages 1164-1168

https://doi.org/10.1016/S0140-6736(87)92142-8 Get rights and content

Abstract

As part of a project within the European Community research activities on acquired immunodeficiency syndrome (AIDS), infants born to human-immunodeficiency-virus-seropositive mothers are being followed up from birth. By October, 1986, 71 infants from Padua, Berlin, and Edinburgh had been followed up to a median age of 6 months (range 1-15 months). Symptoms of AIDS or AIDS-related complex (ARC) had developed in 5, 3 of whom had died. The median age at antibody loss was during the 10th month. An estimated 75% will have lost maternal antibody by 12 months, but loss of antibody did not exclude infection confirmed by virus culture. Numbers were too small to draw conclusions about the risk of AIDS/ARC and mode of delivery or breast-feeding. The study suggested that the risk of AIDS/ARC is higher in infants born to mothers who have AIDS symptoms during pregnancy.

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INFANTS BORN TO MOTHERS SEROPOSITIVE FOR HUMAN IMMUNODEFICIENCY VIRUS: Preliminary Findings from a Multicentre European Study

Abstract

Lancet

Lancet

Lancet

Lancet

Clin Immunol Immunopathol

Lancet

Update: Acquired immunodeficiency syndrome— United States

Morbid Mortal Weekly Rep

Transplacental transmission of HTLV-III virus

N Engl J Med

Human T-cell lymphotropic virus type III (HTLV-III) embryopathy

Am J Dis Child

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Lancet

Acquired immunodeficiency syndrome in infants

N Engl J Med

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J Infect Dis

Neurological manifestations of human immunodeficiency virus infection

Pediatrics

Developmental abnormalities in infants and children with acquired immune deficiency syndrome and AIDS related complex

Develop Med Child Neurol