Research LettersIncreased concentrations of folliclestimulating hormone in mothers of children with Down's syndrome
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The effect of maternal age on the frequency of nondisjunction: change in meiosis or in utero selection?
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Conversion of in vitro fertilization cycles to intrauterine inseminations in patients with a poor ovarian response: Risk of multiple pregnancies
2020, Journal of Gynecology Obstetrics and Human ReproductionCitation Excerpt :On the other hand, the relatively low twin pregnancy rate in women with 3−4 mature follicles in our study could be explained by the low oocyte quality in women with DOR (35 % of the study population) and POR (100 % of study population). Indeed, several studies have reported decreased embryo morphology grades, increased pregnancy losses, and increased aneuploid miscarriages and viable aneuploid pregnancies (trisomy 1318 and 21) in young patients with DOR and POR [23–28]. The overall LBR following conversion to IUI in our study was 7.3 %, which is comparable to rates reported by other studies using the same criteria for conversion to IUI in POR (≤4 follicles ≥ 14 mm with serum estradiol level ≤ 1000 pg/mL on trigger day): 4.1 % in the study by Norian et al. [10] and 7.4 % in the study by Shohieb et al. [20].
Epidemiology and genetics of human aneuploidy
2018, Human Reproductive and Prenatal GeneticsLow oocyte yield during IVF treatment and the risk of a trisomic pregnancy
2017, Reproductive BioMedicine OnlineCitation Excerpt :The definition of diminished ovarian reserve has not been agreed upon, nor whether its features are associated with poor outcomes (Cohen et al., 2015). Previous studies showed inconsistent results on the relation between various parameters reflecting diminished ovarian reserve, e.g. abnormal ovarian test results and previous ovarian surgery, and clinical outcomes, e.g. miscarriages and trisomic pregnancies (Freeman et al., 2000; Grande et al., 2014; Kline et al., 2004, 2011; van Montfrans et al., 1999, 2002). These differences could be caused by variation in definitions of low oocyte yield or diminished ovarian reserve used.
Role of ovarian reserve markers, antimüllerian hormone and antral follicle count, as aneuploidy markers in ongoing pregnancies and miscarriages
2015, Fertility and SterilityCitation Excerpt :Although the clinical utility of AMH reflecting reproductive decline has been extensively studied, scarce data are available on its role as ovarian age marker of aneuploidy risk during pregnancy. Two earlier studies suggested that women with aneuploid pregnancies may have diminished ovarian reserve because increased FSH concentrations were observed (31, 32). However, a more recent study did not detect any differences in FSH, inhibin B, or AFC in trisomic pregnancies (33).