Bone tissue response to biodegradable polymers used for intra medullary fracture fixation: A long-term in vivo study in sheep femora
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Magnetoresponsive stem cell spheroid-based cartilage recovery platform utilizing electromagnetic fields
2020, Sensors and Actuators, B: ChemicalEnhanced performance of magnesium alloy for drug-eluting vascular scaffold application
2018, Applied Surface ScienceCitation Excerpt :It undergoes a degradation process by the simple hydrolysis of an ester bond, and the final products are water and carbon dioxide. A fatal weakness of PLA is that its degradation generates acidic products that lower the local pH value, accelerating further degradation and triggering inflammatory and foreign body reactions [16–18]. Various fruits and vegetables containing ferulic acid, and it is the main effective components in angelicae sinensis [19,20].
Are Biodegradable Plates Applicable in Endoscope-Assisted Open Reduction and Internal Fixation of Mandibular Subcondyle Fractures?
2017, Journal of Oral and Maxillofacial SurgeryScaffold-free, stem cell-based cartilage repair
2016, Journal of Clinical Orthopaedics and TraumaCitation Excerpt :However, there are still several issues regarding the long-term safety and feasibility of these materials. Synthetic polymers, such as polyglycolic acid57 and poly(lactic-co-glycolic acid),58 may have potential problems associated with residual and degradation in situ64,65 that can be the risk factor to cause subsequent inflammation. Biological materials have possibility to transmit infectious agents like bacteria, virus, and prion, which initiate immunological reactions.66,67
Self-deploying shape memory polymer scaffolds for grafting and stabilizing complex bone defects: A mouse femoral segmental defect study
2016, BiomaterialsCitation Excerpt :Prior efforts to apply polymeric materials to fracture healing have often substituted polymers for metals without changing the basic hardware design. These efforts have shown that biodegradable fixation hardware of this type may, in the long-term, be feasible, and may be particularly beneficial in addressing stress-shielding associated with more rigid, non-degradable metal hardware [20–22]. However, inferior mechanical performance (when compared to metal hardware of the same design) and complications arising from poor degradability of highly-compact polymeric material necessary for these approaches has limited progress and translation to date [20–22].