Primary iris stromal cysts: A report of 17 cases☆
Section snippets
Patients and methods
The medical records of all patients with primary iris stromal cysts, examined at the Oncology Service at Wills Eye Hospital between January 1974 and December 1996, were retrospectively reviewed. A total of 17 consecutive patients were included in the study.
The data collected included patient demographics, referring diagnosis, associated systemic and ocular diseases, history of previous trauma or amniocentesis, and use of topical medications. The patients’ symptoms, affected eye, intraocular
Results
Seventeen patients, nine females and eight males, were identified. Nine patients were diagnosed with primary iris stromal cyst under age 10, and eight patients were diagnosed at an older age. Results in both group of patients, 10 years of age or under (children) and over 10 years of age (teenagers and adults), were analyzed separately.
Discussion
Primary, or spontaneous, cysts of the iris stroma are uncommon. Most of the experience accumulated has been based on single case reports3, 6, 7, 8, 9, 10, 11, 15, 16, 17, 18, 19, 20, 23, 26, 27, 28, 29, 30 or small series.2, 4, 5, 12, 13, 14, 32 These cysts have been found most often in children during the first year of life,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 and few cases have been described in adults.2, 15, 16, 17, 18, 19, 20, 21 There appears to be no sex predilection.3, 4, 5, 6, 7, 8, 9
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Intraoperative optical coherence tomography guided iris stromal cyst treatment with absolute alcohol injection
2022, American Journal of Ophthalmology Case ReportsCitation Excerpt :This eventually leads to intraocular complications including angle closure and glaucoma, necessitating surgical intervention.1 Simple aspiration of the iris stromal cyst alone may not be adequate as it tends to recur, especially if it is secondary to trauma or ocular surgery.1,3,4 Shields et al. reported a case series of 16 patients with iris stromal cysts treated with absolute alcohol to induce sclerosis.1
Implantation iris cysts developing 24 years after penetrating keratoplasty
2022, American Journal of Ophthalmology Case ReportsCitation Excerpt :They do not usually lead to complications and therefore do not need to be treated. Implantation cysts of the iris are rarer tumors.3 They are due to the presence of an ectopic epithelium cell inside the iris stroma.
Bilateral congenital stromal iris cyst with secondary glaucoma
2022, American Journal of Ophthalmology Case ReportsCitation Excerpt :Primary iris cysts are usually asymptomatic owing to their stationary or slow-growing nature and are usually an incidental diagnosis. They are more aggressive in younger children and present with secondary complications like glaucoma, uveitis, strabismus, or amblyopia.2,5 Our patient had raised IOP in both eyes.
Sterile iris abscess associated with herpes zoster ophthalmicus
2021, American Journal of Ophthalmology Case ReportsCitation Excerpt :There are various treatment modalities regarding primary and acquired cysts. Congenital iris stromal cysts in children under ten usually require surgical intervention as cysts can rapidly enlarge and rupture, resulting in iritis and glaucoma.9 However, congenital cysts in adolescents or adults only require intervention in about 25% of cases.6
An uncommon case of primary iris cyst managed with Nd YAG laser
2015, Medical Journal Armed Forces IndiaIris cysts: A comprehensive review on diagnosis and treatment
2018, Survey of OphthalmologyCitation Excerpt :Although primary cysts are thought to be congenital, and most of them follow an indolent, stationary, and asymptomatic course (even cases of spontaneous regression have been reported), they sometimes grow slowly over time.4,19,97,176,203 Primary iris stromal cysts usually remain stable in adults, but seem to have a tendency to enlarge and affect the visual axis or cause secondary complications in children.109,138 Depending on the rate of enlargement, symptoms may be delayed until adolescence or early adulthood.206
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Support provided by the Fundación Pedro Barrié de la Maza, La Coruña, Spain; the Eye Tumor Research Foundation, Philadelphia, Pennsylvania; and the Andres Soriano Cancer Research Foundation, Manila, Philippines.